Selected Publications
Cell Biology. Ronning after the adiponectin receptors.
Holland WL, Scherer PE.
Science. 2013 Dec 20;342(6165):1460-1. doi: 10.1126/science.1249077. No abstract available.
 
Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization.
Bates RC, Fees CP, Holland WL, Winger CC, Batbayar K, Ancar R, Bergren T, Petcoff D, Stith BJ.
Dev Biol. 2013 Nov 21. pii: S0012-1606(13)00606-4. doi: 10.1016/j.ydbio.2013.11.006. [Epub ahead of print]
 
Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine.
Unger RH, Scherer PE, Holland WL.
Mol Biol Cell. 2013 Oct;24(19):3011-5. doi: 10.1091/mbc.E12-10-0774.
 
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes.
Gaich G, Chien JY, Fu H, Glass LC, Deeg MA, Holland WL, Kharitonenkov A, Bumol T, Schilske HK, Moller DE.
Cell Metab. 2013 Sep 3;18(3):333-40. doi: 10.1016/j.cmet.2013.08.005.
 
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE.
Cell Metab. 2013 May 7;17(5):790-7. doi: 10.1016/j.cmet.2013.03.019.
Plasma ceramides are elevated in female children and adolescents with type 2 diabetes.
Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer PE.
J Pediatr Endocrinol Metab. 2013;26(9-10):995-8. doi: 10.1515/jpem-2012-0407.
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.
Deng Y, Wang ZV, Tao C, Gao N, Holland WL, Ferdous A, Repa JJ, Liang G, Ye J, Lehrman MA, Hill JA, Horton JD, Scherer PE.
J Clin Invest. 2013 Jan 2;123(1):455-68. doi: 10.1172/JCI62819. Epub 2012 Dec 21.
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.
Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE.
Nat Med. 2012 Oct;18(10):1539-49. doi: 10.1038/nm.2899. Epub 2012 Sep 9.
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex.
Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Pettey D, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD.
Diabetes. 2012 Jul;61(7):1848-59. doi: 10.2337/db11-1399. Epub 2012 May 14.
Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.
Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED.
Endocrinology. 2012 Jun;153(6):2677-88. doi: 10.1210/en.2011-2147. Epub 2012 Apr 17.
Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis.
Bikman BT, Guan Y, Shui G, Siddique MM, Holland WL, Kim JY, Fabriàs G, Wenk MR, Summers SA.
J Biol Chem. 2012 May 18;287(21):17426-37. doi: 10.1074/jbc.M112.359950. Epub 2012 Apr 2.
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA.
J Clin Invest. 2011 May;121(5):1858-70. doi: 10.1172/JCI43378. Epub 2011 Apr 1.
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.
Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, Birnbaum MJ, Summers SA, Scherer PE.
Nat Med. 2011 Jan;17(1):55-63. doi: 10.1038/nm.2277. Epub 2010 Dec 26.
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.
Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK.
Nat Neurosci. 2010 Dec;13(12):1457-9. doi: 10.1038/nn.2664. Epub 2010 Oct 31.
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK.
Cell Metab. 2010 Apr 7;11(4):286-97. doi: 10.1016/j.cmet.2010.03.002.
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ.
J Clin Invest. 2009 Sep;119(9):2577-89. doi: 10.1172/JCI36714. Epub 2009 Aug 10. Erratum in: J Clin Invest. 2010 Jan;120(1):394.
 
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.
Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ.
Diabetes. 2008 Nov;57(11):2958-66. doi: 10.2337/db07-1187. Epub 2008 Aug 26.
 
Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis.
Petcoff DW, Holland WL, Stith BJ.
J Lipid Res. 2008 Nov;49(11):2365-78. doi: 10.1194/jlr.M800159-JLR200. Epub 2008 Jun 24.
 
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.
Holland WL, Summers SA.
Endocr Rev. 2008 Jun;29(4):381-402. doi: 10.1210/er.2007-0025. Epub 2008 May 1. Review.
 
Lipid mediators of insulin resistance.
Holland WL, Knotts TA, Chavez JA, Wang LP, Hoehn KL, Summers SA.
Nutr Rev. 2007 Jun;65(6 Pt 2):S39-46. Review.
 
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.
Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA.
Cell Metab. 2007 Mar;5(3):167-79.
 
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.
Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA.
J Biol Chem. 2005 May 20;280(20):20148-53. Epub 2005 Mar 17.
 
Quantification of phosphatidic acid and lysophosphatidic acid by HPLC with evaporative light-scattering detection.
Holland WL, Stauter EC, Stith BJ.
J Lipid Res. 2003 Apr;44(4):854-8. Epub 2003 Jan 16.
 

 

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