Touchstone Diabetes Center

Publications

Review articles:

1. Oh DY, Kim K, Kwon HB, Seong JY. Cellular and molecular biology of orphan G protein-coupled receptors. International Review of Cytology 2006; 252:95-150

2. Oh DY, Lagakos WS. The role of G-protein-coupled receptors in mediating the effect of fatty acids on inflammation and insulin sensitivity. Curr Opin Clin Nutr Metab Care 2011; 14:322-327

3. Oh DY, Walenta E. The Role of Omega-3 Fatty Acid Receptor GPR120 in Insulin Resistance. Int J Obes Supp 4 2014; 4:S14-S16

4. Oh DY, Walenta E. Omega-3 fatty acids and FFAR4. Front. Endocrinol., 2014;doi: 10.3389/fendo.2014.00115

5. Oh DY, Jerrold M Olefsky. G Protein-Coupled Receptors as Targets for Anti-Diabetic Therapeutics. Nature Reviews Drug Discovery. 2016 Mar;15(3):161-172.

 

Perspective/Preview articles:

1. Oh DY, Olefsky JM. Wnt fans the flames in obesity. Science 2010; 329:397-398

2. Oh DY, Olefsky JM. Omega-3 fatty acids and GPR120. Cell Metab 2012 May; 15:564- 565

 

Research articles:

1. Li P, Liu SN, Lu M, Bandyopadhyay G, Oh DY, Imamura T, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Brenner M, Olefsky JM. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell (Accepted)

2. Gao MH, Giamouridis D, Lai NC, Walenta E, Paschoal VA, Kim YC, Miyanohara A, Guo T, Liao M, Liu L, Tan Z, Ciaraldi T, Schenk S, Bhargava A, Oh DY, Hammond HK. Urocortin 2 Gene Transfer Normalizes Blood Glucose in Murine Type-2 Diabetes. J Clin Invest Insight. (In press)

3. Chen K, Jih A, Kavaler S, Oh DY, Lagakos WS, Kim JJ. Dual actions of a novel bifunctional compound to lower glucose in mice with diet-induced insulin resistance. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E293-301

4. Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab. 2015 Mar 5;4(5):378-391

5. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY*. Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice. Diabetes 2015 Apr;64(4):1120-1130, * Corresponding author

6. Li P*, Oh DY*, Bandyopadhyay G, Lagakos WS, Lu M, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Olefsky JM. LTB4 Stimulation of BLT1 Causes Macrophage-Mediated Inflammation and Directly Induces Decreased Insulin Sensitivity in Obesity. Nat Med 2015 Mar;21(3):239-247, * Co-first author

7. Chung H, Lee YS, Siu J, Oh DY, Mayoral-Monibas R, Webster N, Sears D, Olefsky JM, Ellies L. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene 2014 Sep 15. doi: 10.1038/onc.2014.283.

8. Oh DY*, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi T, Cox JM, Powels MA, Salvo JD, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, Mcnelis J, Bogner-Strauss JG, Olefsky JM. A Gpr120 Selective Agonist Improves Insulin Resistance and Chronic Inflammation. Nat Med 2014 Aug;20(8):942-947, * Corresponding author

9. Lee, YS, Kin JW, Osborn O, Oh DY, Schenk S, Sasik R, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM. Increased Adipocyte O2 Consumption Triggers HIF-1a Causing Inflammation and Insulin Resistance in Obesity. Cell 2014 Jun 5;157(6):1339-1352

10. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WL, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. NCoR KO reprograms macrophage lipid metabolism increasing w-3 fatty acid synthesis and insulin sensitivity. Cell 2013 Sep; 155(1): 200-214

11. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh DY, Li P, Olefsky JM, Saltiel AR. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med 2013 Mar;19(3):313-21

12. Talukdar S*, Oh DY*, Bandyopadhyay G, Xu J, McNelis J, Dongmei Li, Lu M, Li P, Ofrecio JM, Lin M, Brenner MB, Olefsky JM. Neutrophils mediate insulin resistance in high fat diet fed mice via secreted elastase. Nat Med 2012 Sep;18(9):1407-1412 * Co-first author

13. Xu J, Morinaga H, Oh DY, Li P, Chen A, Talukdar S, Olefsky J, Kim JJ. GPR105 ablation improves inflammation and insulin sensitivity in mice with diet-induced obesity. J Immunol 2012 Aug 15;189(4):1992-1999

14. Osborn O, Oh DY, Thiede L, McNelis J, Morinaga H, Talukdar S, Lu M, Li P, Nalbandian S, Sanchez-Alavez M, Hadcock J, Bartfai T, Olefsky JM. Deletion of G protein coupled receptor 21 (Gpr21) improves insulin sensitivity in diet-induced obese mice. J Clin Invest 2012 Jul 2;122(7):2444-2453

15. Bae EJ, Xu J, Oh DY, Bandyopadhyay G, Lagakos WS, Keshwani M, Olefsky JM. Liver specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance. J Biol Chem 2012 May 25;287(22):18769-18780.

16. Nguyen MT, Chen A, Lu WJ, Fan W, Li P, Oh DY, Patsouris D. Regulation of chemokine and chemokine receptor expression by PPARg in adipocyte and macrophages. PLoS One 2012; 7(4):e34976

17. Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky JM. Increased macrophage migration into adipose tissue in obese mice. Diabetes 2012 Feb;61(2):346-354

18. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh DY, Chen A, Bandyopadhyay G, Patsouris D, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Deletion of adipocyte nuclear receptor corepressor (NCoR) enhances adipogenesis and insulin sensitivity. Cell 2011 Nov 11; 147(4):815-826

19. Oh DY, Talukdar S, Bae EJ, Imamura T, Fan W, Morinaga H, Li P, Lu WJ, Watkins SM, Olefsky JM. GPR120 is an Omega-3 polyunsaturated fatty acid receptor and mediates potent anti-inflammatory and insulin sensitizing effects. Cell 2010 Sep 3; 142(5):687-698

20. Yoshizaki T, Schenk S, Imamura T, Babendure J, Sonoda N, Bae EJ, Oh DY, Lu M, Milne J, Westphal C, Bandyopadhyay G, Olefsky JM. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 2009 Dec 8; 298(3): E419

21. Moon JS, Lee YR, Oh DY, Hwang JI, Lee JY, Kim JI, Vaudry H, Kwon HB, Seong JY. Molecular cloning of the bullfrog kisspeptin receptor GPR54 with high sensitivity to Xenopus kisspeptin. Peptides 2009 Jan; 30:171-179

22. Oh DY, Yoon JM, Moon MJ, Hwang JI, Choe H, Lee JY, Kim JI, Kim S, Rhim H, O'Dell DK, Walker JM, Na HS, Lee MG, Kwon HB, Kim K, Seong JY. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem 2008 Jul 25; 283:21054-21064

23. Wang C, Oh DY, Maiti K, Kwon HB, Cheon J, Hwang JI, Seong JY. Involvement of amino acids flanking Glu7.32 of the gonadotropin-releasing hormone receptor in the selectivity of antagonists. Mol Cells 2008 Feb 29; 25:91-98

24. Moon MJ, Oh DY, Moon JS, Kim DK, Hwang JI, Lee JY, Kim JI, Cho S, Kwon HB, Seong JY. Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13. Mol Cell Endocrinol 2007 Oct 15; 277:51-60

25. Cho HJ, Acharjee S, Moon MJ, Oh DY, Vaudry H, Kwon HB, Seong JY. Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands. Gen Comp Endocrinol 2007 Aug-Sep; 153:98-107

26. Song JA*, Oh DY*, Moon JS, Guem D, Kwon HB, Seong JY. Involvement of the Ser-Glu-Pro motif in ligand species-dependent desensitization of the rat gonadotropin-releasing hormone receptor. J Neuroendocri 2006 Oct; 18:1-10. *co-first author

27. Maiti K, Oh DY, Moon JS, Acharjee S, Li JH, Bai DG, Park HS, Lee K, Lee YC, Jung NC, Kim K, Vaudry H, Kwon HB, Seong JY. Differential effects of gonadotropin-releasing hormone-I (GnRH-I) and GnRH-II on prostate cancer cell signaling and death. J Clin Endocrinol Metab 2005 Jul; 90:4287-4298

28. Oh DY, Song JA, Moon JS, Moon MJ, Kim JI, Kim K, Kwon HB, Seong JY. Membrane-proximal region of the carboxyl terminus of the gonadotropin-releasing hormone receptor (GnRHR) confers differential signal transduction between mammalian and nonmammalian GnRHRs. Mol Endocrinol 2005 Mar; 19:722-731

29. Acharjee S, Do-Rego JL, Oh DY, Ahn RS, Choe H, Vaudry H, Kim K, Seong JY, Kwon HB. Identification of amino acid residues that direct differential ligand selectivity of mammalian and nonmammalian V1a type receptors for arginine vasopressin and vasotocin. Insights into molecular coevolution of V1a type receptors and their ligands. J Biol Chem 2004 Dec 24; 279:54445-54453

30. Acharjee S, Do-Rego JL, Oh DY, Moon JS, Ahn RS, Lee K, Bai DG, Vaudry H, Kwon HB, Seong JY. Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors. J Mol Endocrinol 2004 Aug; 33:293-313

31. Wang L, Sanyal S, Oh DY, Kim JY, Ju JW, Song KH, Kim JW, Kwon HB, HS Choi. Molecular cloning and characterization of an amphibian progesterone receptor from Rana dybowskii. Gen Comp Endocrinol 2004 Jan 1; 135:142-149

32. Wang C, Yun O, Maiti K, Oh DY, Kim KK, Chae CH, Lee CJ, Seong JY, Kwon HB. Position of Pro and Ser near Glu7.32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing hormone (GnRH) receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II. Mol Endocrinol 2004 Jan; 18:105-116

33. Oh DY, Wang L, Ahn RS, Park JY, Seong JY, Kwon HB.  Differential G protein coupling preference of mammalian and nonmammalian gonadotropin-releasing hormone receptors. Mol Cell Endocrinol 2003 Jul 31; 205:89-98

34. Seong JY, Wang L, Oh DY, Yun O, Maiti K, Li JH, Soh JM, Choi HS, Kim K, Vaudry H, Kwon HB. Ala/Thr(201) in extracellular loop 2 and Leu/Phe(290) in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction. Endocrinology 2003 Feb; 144:454-466

35. Wang L, Oh DY, Bogerd J, Choi HS, Ahn RS, Seong JY, Kwon HB. Inhibitory activity of alternative splice variants of the bullfrog GnRH receptor-3 on wild-type receptor signaling. Endocrinology 2001 Sep; 142:4015-4025

 

 

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