Touchstone Diabetes Center

Select Publications:

"Sorting out adipocyte precursors and their role in physiology and disease."
Hepler C, Vishvanath L, Gupta RK

Plikus MV1,2, Guerrero-Juarez CF2, Ito M3, Li YR4, Dedhia PH5, Zheng Y1, Shao M6, Gay DL1,7, Ramos R2, His TC2, Oh JW2,8, Wang X2, Ramirez A2, Konopelski SE2, Elzein A2, Wang A1, Supapannachart RJ1, Lee HL2, Lim CH3, Nace A1, Guo A1, Treffeisen E1, Andl T9, Ramirez RN2, Murad R2, Offermanns S10, Metzger D11, Chambon P12, Widgerow AD13, Tuan TL14, Mortazavi A2, Gupta RK6, Hamilton BA15, Millar SE1, Seale P4,16, Pear WS5, Lazar MA4,17, Cotsarelis G1.
"Regeneration of fat cells from myofibroblasts during wound healing.
PMID: 28059714 DOI: 10.1126/science.aai8792

Mengle Shao, Chelsea Hepler, Lavanya Vishvanath, Karen A. MacPherson, Napoleon C. Busbuso, Rana K. Gupta,
Fetal development of subcutaneous white adipose tissue is dependent on Zfp423

Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 2016 Sep 13;24(3):420-33. doi: 10.1016/j.cmet.2016.08.005.
PMID: 27626200

Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, and Gupta RK.  Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Cell Metab. 2016 Jun 14;23(6):1167-84. doi: 10.1016/j.cmet.2016.04.023.
PMID: 27238639

Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE. Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase. Mol Metab. 2015;4(11):771-8. Epub 2015/12/03. doi: 10.1016/j.molmet.2015.08.004. PubMed PMID: 26629402.

Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK, Scherer PE. Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nat Cell Biol. 2015;17(9):1099-111. Epub 2015/08/19. doi: 10.1038/ncb3217. PubMed PMID: 26280538; PMCID: PMC4553131.

Vishvanath L, MacPherson KA, Hepler C, Wang QA, Shao M, Spurgin SB, Wang MY, Kusminski CM, Morley TS, Gupta RK. Pdgfrbeta Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. Cell Metab. 2015. Epub 2015/12/03. doi: 10.1016/j.cmet.2015.10.018. PubMed PMID: 26626462.

Neinast MD, Frank AP, Zechner JF, Li Q, Vishvanath L, Palmer BF, Aguirre V, Gupta RK, Clegg DJ. Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning. Mol Metab. 2015;4(5):427-36. Epub 2015/05/15. doi: 10.1016/j.molmet.2015.02.006. PubMed PMID: 25973390; PMCID: PMC4421080.

Gupta OT, Gupta RK. Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space? Trends Endocrinol Metab. 2015;26(10):515-23. Epub 2015/09/29. doi: 10.1016/j.tem.2015.07.003. PubMed PMID: 26412153.

Ye R, Holland WL, Gordillo R, Wang M, Wang QA, Shao M, Morley TS, Gupta RK, Stahl A, Scherer PE. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes beta-cell regeneration. Elife. 2014;3. Epub 2014/10/24. doi: 10.7554/eLife.03851. PubMed PMID: 25339419; PMCID: PMC4228265.

Wang QA, Scherer PE, Gupta RK. Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. J Lipid Res. 2014;55(4):605-24. Epub 2014/02/18. doi: 10.1194/jlr.R046441. PubMed PMID: 24532650; PMCID: PMC3966696.

Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ. ERalpha upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue. Mol Metab. 2014;3(6):642-51. Epub 2014/08/28. doi: 10.1016/j.molmet.2014.05.007. PubMed PMID: 25161887; PMCID: PMC4142394.

Gupta RK. Adipocytes. Curr Biol. 2014;24(20):R988-93. Epub 2014/12/03. doi: 10.1016/j.cub.2014.09.003. PubMed PMID: 25442852.

Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014;57(6):1209-18. Epub 2014/03/14. doi: 10.1007/s00125-014-3210-3. PubMed PMID: 24623101; PMCID: PMC4106234.

Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med. 2013;19(10):1338-44. Epub 2013/09/03. doi: 10.1038/nm.3324. PubMed PMID: 23995282; PMCID: PMC4075943.

Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012;15(2):230-9. Epub 2012/02/14. doi: 10.1016/j.cmet.2012.01.010. PubMed PMID: 22326224; PMCID: PMC3366493.

Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011;14(6):739-45. Epub 2011/12/14. doi: 10.1016/j.cmet.2011.11.007. PubMed PMID: 22152302; PMCID: PMC3240865.

Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010;464(7288):619-23. Epub 2010/03/05. doi: 10.1038/nature08816. PubMed PMID: 20200519; PMCID: PMC2845731.


Complete List of Published Work by R. Gupta:




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