Touchstone Diabetes Center

Select Publications:

Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice.
Hepler C, Shao M, Xia JY, Ghaben AL, Pearson MJ, Vishvanath L, Sharma AX, Morley TS, Holland WL, Gupta RK.
eLife. 2017; 6.
PubMed [journal]PMID: 28722653

The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.
Hepler C, Gupta RK.
Molecular and cellular endocrinology. 2017; 445:95-108. NIHMSID: NIHMS824546 PubMed [journal]PMID: 27743993 PMCID: PMC5346481

Regeneration of fat cells from myofibroblasts during wound healing.
Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G.
Science (New York, N.Y.). 2017; 355(6326):748-752. NIHMSID: NIHMS857815
PubMed [journal]PMID: 28059714 PMCID: PMC5464786

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.
Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL.
Molecular cell. 2017; 65(2):260-271. NIHMSID: NIHMS828847
PubMed [journal]PMID: 28107648 PMCID: PMC5258183

Sorting out adipocyte precursors and their role in physiology and disease.
Hepler C, Vishvanath L, Gupta RK.
Genes & development. 2017; 31(2):127-140.
PubMed [journal]PMID: 28202540 PMCID: PMC5322728

Fetal development of subcutaneous white adipose tissue is dependent on Zfp423.
Shao M, Hepler C, Vishvanath L, MacPherson KA, Busbuso NC, Gupta RK.
Molecular metabolism. 2017; 6(1):111-124.
PubMed [journal]PMID: 28123942 PMCID: PMC5220400

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.
Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE.
Cell metabolism. 2016; 24(3):420-33. NIHMSID: NIHMS810925
PubMed [journal]PMID: 27626200 PMCID: PMC5024720

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.
Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK.
Cell metabolism. 2016; 23(6):1167-84. NIHMSID: NIHMS783078
PubMed [journal]PMID: 27238639 PMCID: PMC5091077

Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice.
Vishvanath L, MacPherson KA, Hepler C, Wang QA, Shao M, Spurgin SB, Wang MY, Kusminski CM, Morley TS, Gupta RK.
Cell metabolism. 2016; 23(2):350-9. NIHMSID: NIHMS735966
PubMed [journal]PMID: 26626462 PMCID: PMC4749445

Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase.
Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE.
Molecular metabolism. 2015; 4(11):771-8.
PubMed [journal]PMID: 26629402 PMCID: PMC4632120

Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?
Gupta OT, Gupta RK.
Trends in endocrinology and metabolism: TEM. 2015; 26(10):515-23.
PubMed [journal]PMID: 26412153

Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.
Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK, Scherer PE.
Nature cell biology. 2015; 17(9):1099-111. NIHMSID: NIHMS704891
PubMed [journal]PMID: 26280538 PMCID: PMC4553131

Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning.
Neinast MD, Frank AP, Zechner JF, Li Q, Vishvanath L, Palmer BF, Aguirre V, Gupta RK, Clegg DJ.
Molecular metabolism. 2015; 4(5):427-36.
PubMed [journal]PMID: 25973390 PMCID: PMC4421080

Gupta RK.
Current biology : CB. 2014; 24(20):R988-93.
PubMed [journal]PMID: 25442852

ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.
Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ.
Molecular metabolism. 2014; 3(6):642-51.
PubMed [journal]PMID: 25161887 PMCID: PMC4142394

Improved methodologies for the study of adipose biology: insights gained and opportunities ahead.
Wang QA, Scherer PE, Gupta RK.
Journal of lipid research. 2014; 55(4):605-24.
PubMed [journal]PMID: 24532650 PMCID: PMC3966696

Tracking adipogenesis during white adipose tissue development, expansion and regeneration.
Wang QA, Tao C, Gupta RK, Scherer PE.
Nature medicine. 2013; 19(10):1338-44. NIHMSID: NIHMS586873
PubMed [journal]PMID: 23995282 PMCID: PMC4075943

Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM.
Cell metabolism. 2012; 15(2):230-9. NIHMSID: NIHMS378594
PubMed [journal]PMID: 22326224 PMCID: PMC3366493

Transcriptional control of preadipocyte determination by Zfp423.
Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM.
Nature. 2010; 464(7288):619-23. NIHMSID: NIHMS169858
PubMed [journal]PMID: 20200519 PMCID: PMC2845731

Complete List of Published Work by R. Gupta:


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