Touchstone Diabetes Center

2017 Publications             

Primary Papers, Reviews and Commentaries from the Lab in 2017:

Zhang Z, Scherer PE. 2017.
The dysfunctional adipocyte — a cancer cell’s best friend
Nat Rev Endocrinol., in press

Zhu Q, Scherer PE. 2017.
Immunologic and endocrine functions of adipose tissue: implications for kidney disease.
Nat Rev Nephrol., in press

Zhang F, Hao G, Shao M, Hassan G, An YA, Wang Q, Zhu Y, Kusminski CM, Nham K, Gupta RK, Zhai Q, Sun X, Scherer PE*, Oz OK*. 2017.
An Adipose Tissue Atlas: An Image Guided Identification of Human-like BAT and Beige Depots in Rodents.

Cell Metabolism, in press

Xia JY, Sun K, Hepler C, Ghabenn AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE. 2017.
Acute Loss of Adipose Tissue-Derived Adiponectin Triggers Immediate Metabolic Deterioration.
Diabetologia, in press

Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. 2017.
Hepatic GALE Regulates Whole Body Glucose Homeostasis by Modulating Tff3 Expression.
Diabetes, 66(11):2789-2799

Kruglikov IL, Scherer PE. 2017.
General theory of skin reinforcement.
PLoS One. 12(8):e0182865

Kruglikov IL, Scherer PE. 2017.
Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.
Exp Dermatol. 26(6):522-523

An YA, Sun K, Joffin N, Zhang F, Deng Y, Donzé O, Kusminski CM, Scherer PE. 2017.
Angiopoietin-2 in White Adipose Tissue Improves Metabolic Homeostasis through Enhanced Angiogenesis.
eLife, e24071

Tao C, Holland WL, Wang QA, Shao M, Lin J, Sun K,  Lin X, Kuo Y-C, Johnson JA, Gordillo R, Elmquist, JK and P E Scherer. 2017.
Short-Term vs. Long-Term Effects of Adipocyte Toll-like Receptor 4 Activation on Insulin Resistance in Male Mice.
Endocrinology, 158(5):1260-1270

Park J*, Kim M*, Sun K*, An YA*, Gu X and P E Scherer. 2017.
VEGF-A expressing adipose tissue shows rapid beiging, enhanced survival after transplantation and confers IL4-independent metabolic improvements.
Diabetes, 66(6):1479-1490                *equal contributions

Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S and PE Scherer. 2017.
An Adipo-Biliary-Uridine Axis that Regulates Energy Homeostasis.
Science, 355(6330)

Holland WL, Xia JY, Johnson JA, Sun K, Pearson MJ, Sharma AX, Quittner-Strom E, Tippetts TS, Ruth Gordillo R, Scherer PE. 2017.
Mol. Metab., 6(3):267-275

Holland WL and PE Scherer. 2017.
Structural biology: Receptors grease the metabolic wheels.
Nature, 544(7648):42-44

Ghaben AL and PE Scherer. 2017.
Pas de Deux: Glucagon and Thyroid Hormone Moving in Perfect Synchrony
Circulation Res., 120(5):762-764

Crewe C, An YA, Scherer PE. 2017.
The Ominous Triad of Adipose Tissue Dysfunction:
Inflammation, Fibrosis and Impaired Angiogenesis
J. Clin Invest., 127(1):74-82.

Collaborative Papers and Reviews in 2017:

Nav1.8 neurons are involved in limiting acute phase responses to dietary fat.
Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. 2017.
Mol Metab.;6(10):1081-1091.

Vernay A, Marchetti A, Sabra A, Jauslin TN, Rosselin M, Scherer PE, Demaurex N, Orci L, Cosson P. 2017.
MitoNEET-dependent formation of intermitochondrial junctions.
Proc Natl Acad Sci U S A;114(31):8277-8282

Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. 2017.
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.
Am J Pathol. 187(9):1984-1997

Marangoni RG, Masui Y, Fang F, Korman B, Lord G, Lee J, Lakota K, Wei J, Scherer PE, Otvos L, Yamauchi T, Kubota N, Kadowaki T, Asano Y, Sato S, Tourtellotte WG, Varga, J. 2017.
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.
Sci Rep.;7(1):4397

Wang M-Y, Yu X, Lee Y, McCorkle SK, Chen S, Li J, Wang ZV, Davidson JA, Scherer PE, Holland WL, Unger RA, and Roth MG. 2017.
Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.
Proc Natl Acad Sci U S A, 114(25):6611-6616

Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell T, Bisetto S, Velasco-Velàzquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE,  Pestell RG. 2017.
Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis.
Cancer Res., 77(13):3391-3405

Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson J, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V. 2017.
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
Nat. Comm., 8:14395

Tanowitz HB, Scherer PE, Mota MM, Figueiredo LM. 2017.
Adipose tissue - a safe haven for parasites?
Trends in Parasitology, 33(4):276-284

Dufurrena Q, Amjad FM, Scherer PE, Weiss LM, Nagajyothi J, Roth J, Tanowitz HB, Kuliawat R. 2017.
Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies.
Parasitol Res., 116(3):827-838

Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. 2017.
Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.
Nat Med., 23(1):79-90

Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. 2017.
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
J Mol Med (Berl)., 95(3):287-297

Zhang D, Wang X, Wang B, Garza J, Fang X, Wang J, Scherer PE, Brenner R, Zhang W, Lu XY. 2017.
Adiponectin modulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors.
Molecular Psychiatry, 22(7):1044-1055

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