Touchstone Diabetes Center

 

2017 Publications             

Primary Papers, Reviews and Commentaries from the Lab in 2017:

Zhu Q, Scherer PE. 2017.
Immunologic and endocrine functions of adipose tissue: implications for kidney disease.
Nature Reviews Nephrology, in press

Zhang F, Hao G, Shao M, Hassan G, An YA, Wang Q, Zhu Y, Kusminski CM, Nham K, Gupta RK, Zhai Q, Sun X, Scherer PE*, Oz OK*. 2017.
An Adipose Tissue Atlas: An Image Guided Identification of Human-like BAT and Beige Depots in Rodents.

Cell Metabolism, in press

Xia JY, Sun K, Hepler C, Ghabenn AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE. 2017.
Acute Loss of Adipose Tissue-Derived Adiponectin Triggers Immediate Metabolic Deterioration.
Diabetologia, in press

Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. 2017.
Hepatic GALE Regulates Whole Body Glucose Homeostasis by Modulating Tff3 Expression.
Diabetes, 66(11):2789-2799
http://www.ncbi.nlm.nih.gov/pubmed/28877911

Kruglikov IL, Scherer PE. 2017.
General theory of skin reinforcement.
PLoS One. 12(8):e0182865
http://www.ncbi.nlm.nih.gov/pubmed/28797059

Kruglikov IL, Scherer PE. 2017.
Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.
Exp Dermatol. 26(6):522-523
http://www.ncbi.nlm.nih.gov/pubmed/28482134

An YA, Sun K, Joffin N, Zhang F, Deng Y, Donzé O, Kusminski CM, Scherer PE. 2017.
Angiopoietin-2 in White Adipose Tissue Improves Metabolic Homeostasis through Enhanced Angiogenesis.
eLife, e24071
http://www.ncbi.nlm.nih.gov/pubmed/28355132

Tao C, Holland WL, Wang QA, Shao M, Lin J, Sun K,  Lin X, Kuo Y-C, Johnson JA, Gordillo R, Elmquist, JK and P E Scherer. 2017.
Short-Term vs. Long-Term Effects of Adipocyte Toll-like Receptor 4 Activation on Insulin Resistance in Male Mice.
Endocrinology, 158(5):1260-1270
http://www.ncbi.nlm.nih.gov/pubmed/28323977

Park J*, Kim M*, Sun K*, An YA*, Gu X and P E Scherer. 2017.
VEGF-A expressing adipose tissue shows rapid beiging, enhanced survival after transplantation and confers IL4-independent metabolic improvements.
Diabetes, 66(6):1479-1490                *equal contributions
http://www.ncbi.nlm.nih.gov/pubmed/28254844

Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S and PE Scherer. 2017.
An Adipo-Biliary-Uridine Axis that Regulates Energy Homeostasis.
Science, 355(6330)
http://www.ncbi.nlm.nih.gov/pubmed/28302796

Holland WL, Xia JY, Johnson JA, Sun K, Pearson MJ, Sharma AX, Quittner-Strom E, Tippetts TS, Ruth Gordillo R, Scherer PE. 2017.
Mol. Metab., 6(3):267-275
http://www.ncbi.nlm.nih.gov/pubmed/28271033

Holland WL and PE Scherer. 2017.
Structural biology: Receptors grease the metabolic wheels.
Nature, 544(7648):42-44
http://www.ncbi.nlm.nih.gov/pubmed/28329767

Ghaben AL and PE Scherer. 2017.
Pas de Deux: Glucagon and Thyroid Hormone Moving in Perfect Synchrony
Circulation Res., 120(5):762-764
http://www.ncbi.nlm.nih.gov/pubmed/28254797

Crewe C, An YA, Scherer PE. 2017.
The Ominous Triad of Adipose Tissue Dysfunction:
Inflammation, Fibrosis and Impaired Angiogenesis
J. Clin Invest., 127(1):74-82.
http://www.ncbi.nlm.nih.gov/pubmed/28045400

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Collaborative Papers and Reviews in 2017:

Nav1.8 neurons are involved in limiting acute phase responses to dietary fat.
Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. 2017.
Mol Metab.;6(10):1081-1091.
http://www.ncbi.nlm.nih.gov/pubmed/29031710

Vernay A, Marchetti A, Sabra A, Jauslin TN, Rosselin M, Scherer PE, Demaurex N, Orci L, Cosson P. 2017.
MitoNEET-dependent formation of intermitochondrial junctions.
Proc Natl Acad Sci U S A;114(31):8277-8282
http://www.ncbi.nlm.nih.gov/pubmed/28716905

Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. 2017.
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.
Am J Pathol. 187(9):1984-1997
http://www.ncbi.nlm.nih.gov/pubmed/28683257

Marangoni RG, Masui Y, Fang F, Korman B, Lord G, Lee J, Lakota K, Wei J, Scherer PE, Otvos L, Yamauchi T, Kubota N, Kadowaki T, Asano Y, Sato S, Tourtellotte WG, Varga, J. 2017.
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.
Sci Rep.;7(1):4397
http://www.ncbi.nlm.nih.gov/pubmed/28667272

Wang M-Y, Yu X, Lee Y, McCorkle SK, Chen S, Li J, Wang ZV, Davidson JA, Scherer PE, Holland WL, Unger RA, and Roth MG. 2017.
Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.
Proc Natl Acad Sci U S A, 114(25):6611-6616
http://www.ncbi.nlm.nih.gov/pubmed/28584109

Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell T, Bisetto S, Velasco-Velàzquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE,  Pestell RG. 2017.
Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis.
Cancer Res., 77(13):3391-3405
http://www.ncbi.nlm.nih.gov/pubmed/28522753

Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson J, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V. 2017.
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
Nat. Comm., 8:14395
http://www.ncbi.nlm.nih.gov/pubmed/28205547

Tanowitz HB, Scherer PE, Mota MM, Figueiredo LM. 2017.
Adipose tissue - a safe haven for parasites?
Trends in Parasitology, 33(4):276-284
http://www.ncbi.nlm.nih.gov/pubmed/28007406

Dufurrena Q, Amjad FM, Scherer PE, Weiss LM, Nagajyothi J, Roth J, Tanowitz HB, Kuliawat R. 2017.
Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies.
Parasitol Res., 116(3):827-838
http://www.ncbi.nlm.nih.gov/pubmed/28013375

Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. 2017.
Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.
Nat Med., 23(1):79-90
http://www.ncbi.nlm.nih.gov/pubmed/28013375

Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. 2017.
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
J Mol Med (Berl)., 95(3):287-297
http://www.ncbi.nlm.nih.gov/pubmed/27738746

Zhang D, Wang X, Wang B, Garza J, Fang X, Wang J, Scherer PE, Brenner R, Zhang W, Lu XY. 2017.
Adiponectin modulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors.
Molecular Psychiatry, 22(7):1044-1055

http://www.ncbi.nlm.nih.gov/pubmed/27137743

 

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