Touchstone Diabetes Center

 

2016 Publications

 

             

Primary Papers, Reviews and Commentaries from the Lab in 2016

Crewe C, An YA, Scherer PE. 2016.
The Ominous Triad of Adipose Tissue Dysfunction:
Inflammation, Fibrosis and Impaired Angiogenesis
J. Clin Invest., in press

Sun K, Park J, Kim M, Scherer PE. 2016.
Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression , is a predictive biomarker for the response to PPARg agonist treatment.
Diabetologia, 60(1):24-29
https://www.ncbi.nlm.nih.gov/pubmed/27717959

Rutkowski JM, Pastor J, Sun K, Park SC, Bobulescu IA, Chen CT, Moe OW, Scherer PE. 2016.
Adiponectin alters renal calcium and phosphate excretion through regulation of klotho expression.
Kidney International, in press
https://www.ncbi.nlm.nih.gov/pubmed/27914707

Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, TsengY-H, Elmquist JK, Williams KW, Lin HV, Scherer PE. 2016.
Connexin-43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.
Cell Metabolism, 24(3):420-33
http://www.ncbi.nlm.nih.gov/pubmed/27626200

Kruglikov IL, Scherer PE. 2016.
Skin Aging: Are Adipocytes the next target?
Aging-US, 8(7):1457-69
http://www.ncbi.nlm.nih.gov/pubmed/27434510

Turer AT, Scherer PE. 2016.
Adiponectin – just along for the Ride?
Circulation Res., 119(3):407-8
http://www.ncbi.nlm.nih.gov/pubmed/27458194

Scherer PE, Hill JA. 2016.
Obesity, Diabetes, and Cardiovascular Diseases: A Compendium.
Circulation Res., 118(11):1703-5
http://www.ncbi.nlm.nih.gov/pubmed/27230636

Ye R, Wang M, Wang QA, Spurgin SB, Wang ZV, Sun K, Scherer PE. 2016.
Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges.
Mol. Metab., 5 (2016) 437e448
http://www.molecularmetabolism.com/

Wernstedt Asterholm I, Kim JY, Rutkowski JM, Crewe C, Tao C, Scherer PE. 2016.
Pathological Type-2 Immune Response, Enhanced Tumor Growth and Glucose Intolerance in RELMβ Null Mice - A Model of Intestinal Immune System Dysfunction in Disease Susceptibility.
American Journal of Pathology, 186(9):2404-16
http://www.ncbi.nlm.nih.gov/pubmed/27397737

Kusminski CM, Bickel PE, Scherer PE. 2016.
Targeting adipose tissue in the treatment of obesity-associated diabetes.
Nature Drug Discovery, 15(9):639-60
http://www.ncbi.nlm.nih.gov/pubmed/27256476

Wang QA, Scherer PE. 2016.
Human Beige Adipocytes: Epiphenomenon or Drivers of Metabolic Improvements?
Trends Endocrinol Metab., 27(5):244-6
http://www.ncbi.nlm.nih.gov/pubmed/27040112

Scherer PE. 2016.
The Multifaceted Roles of Adipose Tissue - Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture.  
Diabetes, 65(6):1452-61
http://www.ncbi.nlm.nih.gov/pubmed/27222389

Stern JH, Rutkowski JM, Scherer PE. 2016.
Adipose Tissue Crosstalk: Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis.
Cell Metabolism, 23(5):770-84
http://www.ncbi.nlm.nih.gov/pubmed/27166942

Wernstedt Asterholm I, Scherer PE. 2016.
Fibrosis-streaks and splatters: Some things are not always what they seem to be.
Obesity (Silver Spring); 24(3):552-3.
http://www.ncbi.nlm.nih.gov/pubmed/26916237

 

Kusminski CM, Chen S, Ye R, Sun K, Wang QA, Spurgin SB, Sanders PE, Brozinick JT, Li WE, Unger RH and PE Scherer. 2016.
MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival and Intra-Insular Crosstalk.
Diabetes, 65(6):1534-55
http://www.ncbi.nlm.nih.gov/pubmed/26895793

 

Wang ZV,  Scherer PE. 2016.
Adiponectin, the past two decades.
J Mol Cell Biol. 8(2):93-100
http://www.ncbi.nlm.nih.gov/pubmed/26993047

 

Iyengar P, Scherer PE. 2016.
Slim without the gym — the magic of chilling out.
Nature Reviews Endocrinology, 12(5):252-4
http://www.ncbi.nlm.nih.gov/pubmed/26915527

 

Kruglikov IL, Scherer PE. 2016.
Dermal adipocytes and hair cycling: Is spatial heterogeneity a characteristic feature of the dermal adipose tissue depot?
Exp Dermatol., 25(4):258-62
http://www.ncbi.nlm.nih.gov/pubmed/26781768

 

Zhu Y, Crewe C, Scherer PE. 2016.
Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier.
Sci Transl Med., 8(323):323ps4
http://www.ncbi.nlm.nih.gov/pubmed/26819194

 

Kruglikov IK, Scherer PE. 2016
DERMAL ADIPOCYTES: From Irrelevance to Metabolic Targets?
Trends in Endocrinology & Metabolism, 27(1):1-10.
http://www.ncbi.nlm.nih.gov/pubmed/26643658

 

 

______________________________________________________________________

 

Collaborative Papers and Reviews in 2016: 16

Sanada Y, Yamamoto T, Satake R, Yamashita A, Kanai S, Kato N, van de Loo FA, Nishimura F, Scherer PE, Yanaka N. 2016.
Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages.
Sci Rep., in press
https://www.ncbi.nlm.nih.gov/pubmed/27929048

Tanowitz HB, Scherer PE, Mota MM, Figueiredo LM. 2016.
Adipose tissue - a safe haven for parasites?
Trends in Parasitology, in press

Fujikawa T, Castorena CM, Pearson M, Kusminski CM, Ahmed N, Battiprolu PK, Kim KW, Lee S, Hill JA, Scherer PE, Holland WL, Elmquist JK. 2016.
SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise.
Elife; 5. pii: e18206
https://www.ncbi.nlm.nih.gov/pubmed/27874828

Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. 2016.
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.
J Mol Med (Berl). in press
https://www.ncbi.nlm.nih.gov/pubmed/27738746

Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, Yu KJ, Wang RT, Guo H, Yan J, Chang Y, Chen H, Scherer PE, Liu T, Williams KW. 2016.
Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons.
Mol Metab., 5(10):882-91
https://www.ncbi.nlm.nih.gov/pubmed/27689001

Gehrand AL, Hoeynck B, Jablonski M, Leonovicz C, Ye R, Scherer PE, Raff H. 2016.
Sex differences in adult rat insulin and glucose responses to arginine: programming effects of neonatal separation, hypoxia, and hypothermia.
Physiol Rep.; 4(18).
https://www.ncbi.nlm.nih.gov/pubmed/27664190

Haas ME, Levenson AE, Sun X, Rutkowski JM, Nephrotic Syndrome Study Network, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. 2016.
PCSK9 as a Mediator of Nephrotic Syndrome-associated Hypercholesterolemia.
Circulation, 134(1):61-72
http://www.ncbi.nlm.nih.gov/pubmed/27358438

Peri-Okonny PA, Ayers C, Maalouf N, Das SR, de Lemos JA, Berry JD, Turer AT, Neeland IJ, Scherer PE, Vongpatanasin W. 2016.
Adiponectin predicts incident hypertension independent of body fat distribution: observations from the Dallas Heart Study.
Diabetes Metab Res Rev., in press
http://www.ncbi.nlm.nih.gov/pubmed/27455039

Kruglikov IL, Scherer PE, Wollina U. 2016.
Are dermal adipocytes involved in psoriasis?
Exp Dermatol., 25(10):812-3
http://www.ncbi.nlm.nih.gov/pubmed/26913468

 

Senol-Cosar O, Roth Flach R, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Gupta O, Noh HL, Kim J, Wabitsch M, Scherer PE, Czech M. 2016.
Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.
Nat. Comm., 16;7:10686
http://www.ncbi.nlm.nih.gov/pubmed/26880110

 

Davidson JA, Holland WL, Roth MG, Wang MY, Lee Y, Yu X, McCorkle SK, Scherer PE, Unger RH. 2016.
Glucagon therapeutics, dawn of a new era for diabetes care.
Diabetes Metab Res Rev., 32(7):660-665
http://www.ncbi.nlm.nih.gov/pubmed/26729301

 

Dasuri K, Pepping JK, Fernandez-Kim SOK, Gupta S, Keller JN, Scherer PE, Bruce-Keller AJ. 2016.
Elevated Adiponectin Prevents HIV Protease Inhibitor Toxicity and Preserves Cerebrovascular Homeostasis in Mice.
BBA - Molecular Basis of Disease, 1862(6):1228-35
http://www.ncbi.nlm.nih.gov/pubmed/26912411

 

Zhang D, Wang X, Wang B, Garza J, Fang X, Wang J, Scherer PE, Brenner R, Zhang W, Lu XY. 2016.
Adiponectin modulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors.
Molecular Psychiatry, in press

http://www.ncbi.nlm.nih.gov/pubmed/27137743

 

Valero-Munoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE , Sam F. 2016.
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.
Circ Heart Fail., 9(1):e002724
http://www.ncbi.nlm.nih.gov/pubmed/26721917

 

Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. 2016.
A role of the Inflammasome in the low storage capacity of the abdominal subcutaneous adipose tissue in obese adolescents.
Diabetes, 65(3):610-8
http://www.ncbi.nlm.nih.gov/pubmed/26718495

 

Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. 2016

Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.

J Mol Med (Berl). in press

https://www.ncbi.nlm.nih.gov/pubmed/27738746

2015 Publications

Tan CY*, Virtue S*, Murfitt S, Yi HP, Dale M, Griffin J, Tinahones F, Scherer PE, Vidal-Puig A. 2015.
Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.
Sci Rep., 5:18366
http://www.ncbi.nlm.nih.gov/pubmed/26679101

Ye R*, Wang QA*, Tao C, Vishvanath L, Shao, M, McDonald, JG, Gupta RK, Scherer PE. 2015.
Impact of Tamoxifen on Adipocyte Lineage Tracing: Inducer of Adipogenesis and Prolonged Nuclear Translocation of Cre Recombinase.
Mol. Metabolism., 4(11):771-8                      *equal contributions
http://www.ncbi.nlm.nih.gov/pubmed/26629402

Kusminski CM, Gallardo Montejano V, Wang ZV, Hegde V, Bickel PE, Dhurandhar N, Scherer PE. 2015.
E4orf1 Induction in Adipose Tissue Promotes Insulin-independent Signaling in the Adipocyte.
Mol. Metabolism., 4(10):653-64
http://www.ncbi.nlm.nih.gov/pubmed/26500839

Xia* JX, Holland* WL, Kusminski CM, Sun K, Sharma AX, Pearson MJ, Sifuentes AJ, McDonald JG, Gordillo R and PE Scherer. 2015.         *equal contribution
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.
Cell Metabolism, 22(2):266-278
http://www.ncbi.nlm.nih.gov/pubmed/26190650

Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK and PE Scherer. 2015.
Distinct Regulatory Mechanisms Govern Embryonic versus Adult Adipocyte Maturation.
Nat. Cell Biol., 17(9):1099-111
http://www.ncbi.nlm.nih.gov/pubmed/26280538

Morley TS, Xia JX and PE Scherer. 2015.
Selective Enhancement of Insulin Sensitivity in the Mature Adipocyte is Sufficient for Systemic Metabolic Improvements.
Nature Comm., 6:7906
http://www.ncbi.nlm.nih.gov/pubmed/26243466

Ye R, Wang M, Qiong A, Wang QA, Scherer PE. 2015.
Adiponectin-mediated anti-lipotoxic effects in regenerating pancreatic islets.
Endocrinology, 156(6):2019-28
http://www.ncbi.nlm.nih.gov/pubmed/25815422

Kusminski CM, Scherer PE. 2015.
Leptin beyond the lipostat: key component of blood pressure regulation.
Circ Res., 116(8):1293-5
http://www.ncbi.nlm.nih.gov/pubmed/25858061

Rutkowski JM, Stern JH, Scherer PE. 2015.
The Cell Biology of Fat Expansion.
J. Cell Biol., 208(5):501-512
http://www.ncbi.nlm.nih.gov/pubmed/25733711

Stern JH and P E Scherer. 2015.
Adipose Tissue Biology in 2014.
ADVANCES IN OUR UNDERSTANDING OF ADIPOSE TISSUE HOMEOSTASIS
Nat Rev Endocrinol.; 11(2):71-2
http://www.ncbi.nlm.nih.gov/pubmed/25511312

Warshauer JT, Lopez X, Gordillo R, Hicks J, Holland WL, Anuwe E, Blankfard M, Scherer PE, Lingvay I. 2015.
Effect of Pioglitazone on Plasma Ceramides in Adults with Metabolic Syndrome.
Diabetes Metab Res Rev., 31(7):734-44
http://www.ncbi.nlm.nih.gov/pubmed/25959529

Mansuy-Aubert V, Gautron L, Lee S, Bookout AL, Kusminski C, Sun K, Zhang Y, Scherer PE, Mangelsdorf DJ, Elmquist JK. 2015.
Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.
Elife.   eLife.06667
http://www.ncbi.nlm.nih.gov/pubmed/26076474

Marangoni RG, Korman B, Wei J, Wood TA, Graham L, Whitfield ML, Scherer PE, Tourtellotte WG J Varga. 2015
Myofibroblasts in cutaneous fibrosis originate from adiponectin-positive intradermal progenitors.
Arthritis Rheumatol. 156(4):1504-13
http://www.ncbi.nlm.nih.gov/pubmed/25504959

Stone KP, Wanders D, Calderon LF, Spurgin SB, Scherer PE,  Gettys TW. 2015.
Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice.
Obesity, 23(9):1836-44
http://www.ncbi.nlm.nih.gov/pubmed/26237535

Combs TP, Snell-Bergeon JK, Maahs DM, Bergman BC, Lamarche M, Iberkleid L, Abdel Baky O, Tisch R, Scherer PE and Marliss EB. 2015.
Adiponectin: SOGA Dissociation in Type 1 Diabetes.
J Clin Endocrinol Metab., 100(8):E1065-73.
http://www.ncbi.nlm.nih.gov/pubmed/26052615

Burrill JS, Long, EK, Reilly B, Deng Y, Armitage IM, Scherer PE and DA Bernlohr. 2015.
Inflammation and ER Stress Regulate Branched Chain Amino Acid Uptake and Metabolism in Adipocytes.
Mol Endocrinol, 29(3):411-20
http://www.ncbi.nlm.nih.gov/pubmed/25635940

Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A, Wan Y. 2015.
Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation.
Endocrinology, 156(4):1504-13
http://www.ncbi.nlm.nih.gov/pubmed/25590242

Gunter MJ, Wang T, Cushman M, Xue X, Wassertheil-Smoller S, Strickler HD, Rohan TE, Manson JE, McTiernan A, Kaplan RC, Scherer PE, Chlebowski RT, Snetselaar L, Wang D, Ho GYF. 2015.
Circulating Adipokines and Inflammatory Markers and Postmenopausal Breast Cancer Risk.
J. Natl Cancer Inst., 16;107(9)
http://www.ncbi.nlm.nih.gov/pubmed/26185195

Beg MS, Saleem S, Turer A, Ayers C, de Lemos JA, Khera A, Scherer PE, Lakoski SG. 2015.
A Prospective Analysis of Plasma Adiponectin and Risk of Incident Cancer: The Dallas Heart Study.
J Natl Compr Canc Netw., 13(7):873-8
http://www.ncbi.nlm.nih.gov/pubmed/26150581

de Seigneux S, Courbebaisse* M, Rutkowski* JM, Wilhelm- Bals* A, Metzger M, Khodo SN, Hasler U, Chehade H, Dizin E, Daryadel A, Stengel B for the NEPHROTEST study group, Girardin E, Prié D, Wagner CA, P E Scherer , Martin P-Y, Houillier P and E Feraille. 2014.
Proteinuria increases plasma phosphate by altering its tubular handling.
J Am Soc Nephrol., 26(7):1608-18

http://www.ncbi.nlm.nih.gov/pubmed/25349200

Hansen MT, Forst B, Cremers N, Quagliata L, Ambartsumian N, Grum-Schwensen B, Klingelhöfer J, Abdul Al A, Herrmann P, Osterland M, Stein U, Nielsen G, P E Scherer PE, Lukanidin E, Sleeman JP and M Grigorian. 2015.
A link between inflammation and metastasis: Serum Amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4.
Oncogene, 34(4):424-35
http://www.ncbi.nlm.nih.gov/pubmed/24469032

2014 Publications

Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R and EN Olson. 2014.
MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
EMBO Mol Med.;6(12):1610-21.
http://www.ncbi.nlm.nih.gov/pubmed/25422356

Burke S, Nagajyothi F, Thi MM, Hanani M, Scherer PE, Tanowitz HB, Spray DC. 2014.
Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: implications for Chagas disease.
Microbes Infect.;16(11):893-901.
http://www.ncbi.nlm.nih.gov/pubmed/25150689

Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG and RH Unger. 2014.
Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells.
Proc Natl Acad Sci U S A.;111(36):13217-22
http://www.ncbi.nlm.nih.gov/pubmed/25157166

Tanaka K, Wilson RM, Essick EE, Duffen JL, Scherer PE, Ouchi N and F. Sam. 2014.
Effects of adiponectin on calcium-handling proteins in heart failure with preserved ejection fraction.
Circ Heart Fail.; 7(6):976-85.
http://www.ncbi.nlm.nih.gov/pubmed/25149095

Ryu TY, Park J, and P E Scherer. 2014.
Hyperglycemia as a risk factor for cancer progression.
Diabetes Metab J., 38(5):330-6
http://www.ncbi.nlm.nih.gov/pubmed/25349819

Nagajyothi F, Weiss LM, Zhao D, Koba W, Jelicks LA, Cui MH, Factor SM,

P E Scherer and HB Tanowitz. 2014.
High Fat Diet Modulates Trypanosoma cruzi Infection Associated Myocarditis.
PLoS Negl Trop Dis 8(10): e3118.
http://www.ncbi.nlm.nih.gov/pubmed/25275627

Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, P E Scherer and DJ Clegg. 2014.
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.
Mol Metab.;3(6):642-51
http://www.ncbi.nlm.nih.gov/pubmed/25161887

Ye R, Holland WL, Gordillo R, Wang M, Wang QA, Shao M, Morley TS, Gupta, RK, Stahl A, and P E Scherer. 2014. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. eLife, 3:e03851

http://www.ncbi.nlm.nih.gov/pubmed/25339419

Wernstedt Asterholm I, Tao C, Morley TS, Wang QA, Delgado-Lopez F,
Wang ZV and P E Scherer. 2014. Adipocyte Inflammation is Essential
for Healthy Adipose Tissue Expansion and Remodeling.
Cell Metabolism, 20(1):103-18
http://www.ncbi.nlm.nih.gov/pubmed/24930973

 

Kusminski CM, Park JY and P E Scherer. 2014.
MitoNEET-Mediated Effects on Browning of White Adipose Tissue
Nature Comm, 5:3962

http://www.ncbi.nlm.nih.gov/pubmed/24865177

Lin J, Vianna C, Fukuda M, Berglund E, Liu C, Tao C, Sun K, Liu T, Harper M, Lee CE, Lee S, P E Scherer* and JK Elmquist*. 2014.
*co-corresponding authors
Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance
Nature Comm, 5:3878

http://www.ncbi.nlm.nih.gov/pubmed/24815961

Williams KW, Liu T, Kong X, Fukuda M, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn J-W Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang, Y., P E Scherer .* and J. K. Elmquist*. 2014. *co-senior authors
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis
Cell Metabolism, 20(3):471-82
http://www.ncbi.nlm.nih.gov/pubmed/25017942

Park* J, Morley* T S, Kim M, Clegg DJ and P E Scherer. 2014
Obesity and Cancer: Underlying Mechanisms for Progression and Recurrence
Nat Rev Endocrinol., 10(8):455-65
*equal contribution
http://www.ncbi.nlm.nih.gov/pubmed/24935119

Sun K, Kusminski CM, Luby-Phelps K, Spurgin SB, An YA,

Wang QA, Holland WL and P E Scherer. 2014.
Brown Adipose Tissue Derived VEGF-A Modulates Cold Tolerance and Energy Expenditure

Mol Metabolism, 3(4):474-83
http://www.molmetab.com/article/S2212-8778%2814%2900077-5/abstract?rss=yes

Sun* K, Park* J, Gupta O, Holland WL, Landrock Auerbach P, Zhang N, Goncalves Marangoni R, Nicoloro SM, Czech MP, Varga J, Ploug T, An Z and

P E Scherer. 2014.
Endotrophin Triggers Adipose Tissue Inflammation and Metabolic Dysfunction
Nature Comm, 5:3485 * equal contribution
http://www.ncbi.nlm.nih.gov/pubmed/24647224

Wernstedt Asterholm* I, Rutkowski* JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK And P E Scherer. 2014.
Elevated Resistin Levels Induce Central Leptin Resistance and Increased Atherosclerotic Progression
Diabetologia, 57(6):1209-1 * equal contribution
http://www.ncbi.nlm.nih.gov/pubmed/24623101

Rutkowski JM, Halberg N, Wang QA, Holland WL, Xia JX and P E Scherer. 2014.
Differential transendothelial transport of adiponectin complexes
Cardiovascular Diabetology, (1):47
http://www.ncbi.nlm.nih.gov/pubmed/24552349

Ye R and P E Scherer. 2014.
Fabp4, a New Player in the Adipo-Pancreatic Axis

Mol. Metabolism, 3(4):347-8
http://www.molmetab.com/article/S2212-8778%2814%2900076-3/abstract?rss=yes

Wen JJ, Nagajyothi F, Machado FS, Weiss LM, P E Scherer , Tanowitz HB and NJ Garg. 2014.
Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection.
Parasitol Res., 113(9):3159-65
http://www.ncbi.nlm.nih.gov/pubmed/24948102

Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, P E Scherer , Lowell BB and JK Elmquist. 2014.
Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia.

Nat Neurosci., 17(7):911-3

http://www.ncbi.nlm.nih.gov/pubmed/24908101

Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J,P E Scherer , Dong LQ and F Liu. 2014.
Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1

Cell Metabolism, 19(6):967-80.

http://www.ncbi.nlm.nih.gov/pubmed/24746805

Samocha-Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietiläinen KH, Rabasa-Lhoret R, Roden M, P E Scherer , Klein S and E Ravussin. 2014.
Metabolically healthy and unhealthy obese - the 2013 Stock Conference report
Obes Rev., 15(9):697-708
http://www.ncbi.nlm.nih.gov/pubmed/25059108

P E Scherer . 2014.
Preface
For a review series on Adiponectin
Best Pract Res Clin Endocrinol Metab. 28(1):1-2
http://www.ncbi.nlm.nih.gov/pubmed/24417940

Wang QA and P E Scherer. 2014.
The AdipoChaser Mouse: A Model Tracking Adipogenesis in vivo
Adipocyte, 3(2):146-50
http://www.ncbi.nlm.nih.gov/pubmed/24719789

Rutkowski JM and P E Scherer. 2014.
Isolation and Quantitation of Adiponectin Higher Order Complexes
Volume: Methods of Adipose Tissue Biology; Edited by O.A. MacDougald
Methods in Enzymology, 537:243-59
http://www.ncbi.nlm.nih.gov/pubmed/24480350

Pessa, J.E., Nguyen, H., John, G.B. and P E Scherer . 2014.
The anatomical basis for wrinkles.
Aesthet Surg J., 34(2):227-34.
http://www.ncbi.nlm.nih.gov/pubmed/24353247

Holland WL and PE Scherer. 2013.
Ronning After The Adiponectin Receptors
Science, 342(6165):1460-1
http://www.ncbi.nlm.nih.gov/pubmed/24357309

Wang ZV, Deng Y, GaoN, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette TG, P E Scherer and J A Hill. 2014.
Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway.
Cell, 156, 1179–1192
http://www.ncbi.nlm.nih.gov/pubmed/24630721

Wang QA , P E Scherer and R K Gupta. 2014.
Improved Methodologies for the Study of Adipose Biology:
Insights Gained and Opportunities Ahead
J. Lipid Research, 55(4):605-24
http://www.ncbi.nlm.nih.gov/pubmed/24532650

Liu C, Bookout AL, Lee S, Sun K, Jia L, Lee C, Udit S, Deng Y, P E Scherer, Mangelsdorf DJ, Gautron L and J K Elmquist. 2014
PPARγ in Vagal Neurons Regulates High-Fat Diet Induced Thermogenesis
Cell Metabolism, 19(4), 722-730
http://www.ncbi.nlm.nih.gov/pubmed/24703703

Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J,P E Scherer, Dong LQ and F Liu. 2014.
Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1
Cell Metabolism, in press
http://www.ncbi.nlm.nih.gov/pubmed/24746805

Mundy DI, Lopez AM, Posey KS, Chuang JC, Ramirez CM, P E Scherer and SD Turley. 2014.
Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1.
Biochim Biophys Acta., 1841(7):995-1002
http://www.ncbi.nlm.nih.gov/pubmed/24747682

Bueno AC, Sun K, Martins C, Junior J E, Miranda W, Tao C, Foss-Freitas MC, Barbieri MA, Bettiol H, de Castro M, P E Scherer and SR Antonini. 2014.
A Novel ADIPOQ Mutation (p.M40K) Impairs Assembly of High-Molecular-Weight Adiponectin and Is Associated With Early-Onset Obesity and Metabolic Syndrome
J Clin Endocrinol Metab., 99(4):E683-93
http://www.ncbi.nlm.nih.gov/pubmed/24432991

Zhu H, Guariglia S, Li W, Brancho B, Wang ZV, P E Scherer and CW Chow. 2014.
Role of Extracellular Signal-Regulated Kinase 5 in Adipocyte Signaling
J. Biol. Chem., 289(9):6311-22
http://www.ncbi.nlm.nih.gov/pubmed/24425864

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, P E Scherer, Williams NS, Tambar UK, Wynn RM and DT Chuang. 2014.
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
J Biol Chem., 289(7):4432-43
http://www.ncbi.nlm.nih.gov/pubmed/24356970

Lackey DE, Burk DH, Ali MR, Mostaedi R, Smith WH, Park J, P E Scherer, Seay SA, McCoin CS, Bonaldo PE and SH Adams. 2014.
Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity
Am J Physiol Endocrinol Metab, 306(3):E233-46
http://www.ncbi.nlm.nih.gov/pubmed/24302007

Mitsnefes, M, P E Scherer , Aronson Friedman, L, Gordillo, R, Furth, S, Warady, B for the CKiD study group. 2014.
Ceramides and cardiac function in children with chronic kidney disease Pediatric Nephrology
Pediatr Nephrol, 29(3):415-22
http://www.ncbi.nlm.nih.gov/pubmed/24389650

 

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